Phenotype and Antimicrobial Activity of Th17 Cells Induced by Propionibacterium acnes Strains Associated with Healthy and Acne Skin.

ABSTRACT: Studies of the human skin microbiome suggest that Propionibacterium acnes strains may contribute differently to skin health and disease. However, the immune phenotype and functions of T helper type 17 (Th17) cells induced by healthy (P_H) versus acne (P_A) skin-associated P. acnes strains are currently unknown. We stimulated peripheral blood mononuclear cells from healthy donors and observed that P_A strains induce higher IL-17 levels than P_H strains. We next generated P_H and P_A strain-specific Th17 clones and show that P. acnes strains induce Th17 cells of varied phenotype and function that are stable in the presence of IL-2 and IL-23. Although P_H- and P_A-specific clones expressed similar levels of LL-37

SUBMITTER: Agak GW 

PROVIDER: S-EPMC5794628 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature