Post-Treatment/Pre-operative PET Response Is Not an Independent Predictor of Outcomes for Patients With Gastric and GEJ Adenocarcinoma.

ABSTRACT:

Objective

To determine whether changes in positron emission tomography (PET) avidity correlated with histologic response and were independently associated with outcome.

Background

The implications of metabolic response to neoadjuvant therapy as measured by repeat PET imaging remain ill-defined for patients with gastric and gastroesophageal junction (GEJ) cancers.

Methods

We identified patients with gastric and GEJ adenocarcinoma who were evaluated with PET imaging before and following neoadjuvant treatment, and subsequently underwent curative resections. Spearman rank correlation and Cox proportional hazards regression were used to evaluate standardized uptake value (SUV) and histologic response, pathologic parameters, and disease-specific survival (DSS).

Results</

SUBMITTER: Hernandez JM 

PROVIDER: S-EPMC5794647 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature