Metabolites and microbial composition of stool of women with fecal incontinence: Study design and methods.

ABSTRACT:

Aims

This paper aims to report the rationale, design, and the specific methodology of an ongoing nested observational study that will determine the association of the metabolite and microbial composition of stool with fecal incontinence (FI).

Methods

Eligible cases are participants with FI enrolled in the Controlling Anal Incontinence in women by Performing Anal Exercises with Biofeedback or Loperamide (CAPABLe) trial, a Pelvic Floor Disorders Network trial across eight clinical centers in the United States. Women of similar age without FI in the last year served as controls. All subject collected stool samples at the baseline and 24-week visit at home using a standardized collection method. Samples were shipped to and stored at centralized laboratories.

Results

Speci

SUBMITTER: Arya LA 

PROVIDER: S-EPMC5794661 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature