The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system with unknown etiology. Recently, the gut microbiota has emerged as a potential factor in the development of MS, with a number of studies having shown that patients with MS exhibit gut dysbiosis. The gut microbiota helps the host remain healthy by regulating various functions, including food metabolism, energy homeostasis, maintenance of the intestinal barrier, inhibition of colonization by pathogenic organisms, and shaping of both mucosal and systemic immune responses. Alteration of the gut microbiota, and subsequent changes in its metabolic network that perturb this homeostasis, may lead to intestinal and systemic disorders such as MS. Here we discuss the findings of recent MS microbiome studies a

SUBMITTER: Freedman SN 

PROVIDER: S-EPMC5794701 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature