MsgbsR: An R package for analysing methylation-sensitive restriction enzyme sequencing data.

ABSTRACT: Genotyping-by-sequencing (GBS) or restriction-site associated DNA marker sequencing (RAD-seq) is a practical and cost-effective method for analysing large genomes from high diversity species. This method of sequencing, coupled with methylation-sensitive enzymes (often referred to as methylation-sensitive restriction enzyme sequencing or MRE-seq), is an effective tool to study DNA methylation in parts of the genome that are inaccessible in other sequencing techniques or are not annotated in microarray technologies. Current software tools do not fulfil all methylation-sensitive restriction sequencing assays for determining differences in DNA methylation between samples. To fill this computational need, we present msgbsR, an R package that contains tools for the analysis of methylation-sensit

SUBMITTER: Mayne BT 

PROVIDER: S-EPMC5794748 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature