Grey matter OPCs are less mature and less sensitive to IFNγ than white matter OPCs: consequences for remyelination.

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory disease characterized by the formation of demyelinated lesions in the central nervous system. At later stages of the disease repair in the form of remyelination often fails, which leads to axonal degeneration and neurological disability. For the regeneration of myelin, oligodendrocyte progenitor cells (OPCs) have to migrate, proliferate and differentiate into remyelinating oligodendrocytes. Remyelination occurs faster and is more extensive in grey matter (GM) lesions than in white matter (WM) lesions. Here, we examined differences in neonatal OPCs from GM (gmOPCs) and WM (wmOPCs), both intrinsically and in response to environmental (injury) signals. We show that gmOPCs are less mature than wmOPCs, both on morphological and on gene-expressio

SUBMITTER: Lentferink DH 

PROVIDER: S-EPMC5794790 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature