The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression.

ABSTRACT:

Background

The nuclear factor-kappa B (NF-κB) signalling pathway is a regulator of immune response and inflammation that has been implicated in the carcinogenic process. We examined differentially expressed genes in this pathway and miRNAs to determine associations with colorectal cancer (CRC).

Methods

We used data from 217 CRC cases to evaluate differences in NF-κB signalling pathway gene expression between paired carcinoma and normal mucosa and identify miRNAs that are associated with these genes. Gene expression data from RNA-Seq and miRNA expression data from Agilent Human miRNA Microarray V19.0 were analysed. We evaluated genes most strongly associated and differentially expressed (fold change (FC) of > 1.5 or < 0.67) that were statistically significant after adjustment

SUBMITTER: Slattery ML 

PROVIDER: S-EPMC5794831 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature