Expanding horizons in complement drug discovery: challenges and emerging strategies.

ABSTRACT: The complement system is best known for its role in innate immunity, providing a first line of defence against infection, maintaining tissue homeostasis by flagging apoptotic cells and debris for removal, and orchestrating crosstalk between adaptive and innate immunity. In a growing number of diseases, complement is known to drive pathogenesis or to contribute as an inflammatory amplifier of a disease trigger. Association of complement with common and devastating diseases has driven an upsurge in complement drug discovery, but despite a wealth of knowledge in the complexities of the cascade, and many decades of effort, very few drugs have progressed to late-stage clinical studies. The reasons for this are becoming clear with difficulties including high target concentration and turnover, la

SUBMITTER: Harris CL 

PROVIDER: S-EPMC5794834 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature