Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review.

ABSTRACT: Neuroinflammation is proposed as one of the mechanisms by which Alzheimer's disease pathology, including amyloid-β plaques, leads to neuronal death and dysfunction. Increases in the expression of markers of microglia, the main neuroinmmune cell, are widely reported in brains from patients with Alzheimer's disease, but the literature has not yet been systematically reviewed to determine whether this is a consistent pathological feature. A systematic search was conducted in Medline, Embase and PsychINFO for articles published up to 23 February 2017. Papers were included if they quantitatively compared microglia markers in post-mortem brain samples from patients with Alzheimer's disease and aged controls without neurological disease. A total of 113 relevant articles were identified. Consisten

SUBMITTER: Hopperton KE 

PROVIDER: S-EPMC5794890 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature