OTTO: a new strategy to extract mental disease-relevant combinations of GWAS hits from individuals.

ABSTRACT: Despite high heritability of schizophrenia, genome-wide association studies (GWAS) have not yet revealed distinct combinations of single-nucleotide polymorphisms (SNPs), relevant for mental disease-related, quantifiable behavioral phenotypes. Here we propose an individual-based model to use genome-wide significant markers for extracting first genetic signatures of such behavioral continua. 'OTTO' (old Germanic=heritage) marks an individual characterized by a prominent phenotype and a particular load of phenotype-associated risk SNPs derived from GWAS that likely contributed to the development of his personal mental illness. This load of risk SNPs is shared by a small squad of 'similars' scattered under the genetically and phenotypically extremely heterogeneous umbrella of a schizophrenia e

SUBMITTER: Ehrenreich H 

PROVIDER: S-EPMC5794905 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature