A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer.

ABSTRACT:

Background

Nitric oxide (NO) has been highlighted as an important agent in cancer-related events. Although the inducible nitric oxide synthase (iNOS) isoform has received most attention, recent studies in the literature indicate that the endothelial isoenzyme (eNOS) can also modulate different tumor processes including resistance, angiogenesis, invasion, and metastasis. However, the role of eNOS in cancer stem cell (CSC) biology and mesenchymal tumors is unknown.

Results

Here, we show that eNOS was significantly upregulated in VilCre ^ERT2 Apc ^fl/+ and VilCre ^ERT2 Apc ^fl/fl mouse intestinal tissue, with intense immunostaining in hyperproliferative crypts. Similarly, the more invasive VilCre ^ERT2 Apc ^fl/+ Pten <

SUBMITTER: Penarando J 

PROVIDER: S-EPMC5795284 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature