Transcription factor PU.1 is involved in the progression of glioma.

ABSTRACT: Glioma is a severe disease of the central nervous system. Although previous studies have identified the important role of the immune response in association with tumor intervention, it is still unknown whether PU.1, a transcription factor known for its role in myeloid differentiation and immune responses, is involved in the progression of glioma. In the present study, we found a significant increase in SPI1, the gene that encodes PU.1, in samples from patients with glioma. Through genotype-phenotype association analysis several candidate factors that may mediate the role of PU.1 in glioma were identified. To further validate the association between PU.1 and glioma we found that the expression of BTK, a potential target of PU.1, was also upregulated in patients with glioma. We also demonstr

SUBMITTER: Xu Y 

PROVIDER: S-EPMC5795926 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature