Ontology highlight
ABSTRACT:
SUBMITTER: Caggiari L
PROVIDER: S-EPMC5795997 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20171223 1
The <i>CDH1</i> gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. The human epidermal growth factor receptor 2 (<i>HER2</i>) is amplified and overexpressed in a portion of GC. <i>HER2</i> is an established therapeutic target in metastatic GC (mGC). Trastuzumab, in combination with various chemotherapeutic agents, is a standard treatment for these tumors leading to outcome improvement. Unfortunately, the survival benefit is limited to a f ...[more]