Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers.

ABSTRACT: Natural antisense transcripts are RNA sequences that can be transcribed from both DNA strands at the same locus but in the opposite direction from the gene transcript. Because strand-specific high-throughput sequencing of the antisense transcriptome has only been available for less than a decade, many natural antisense transcripts were first described as long non-coding RNAs. Although the precise biological roles of natural antisense transcripts are not known yet, an increasing number of studies report their implication in gene expression regulation. Their expression levels are altered in many physiological and pathological conditions, including breast cancers. Among the potential clinical utilities of the natural antisense transcripts, the non-coding|coding transcript pairs are of high in

SUBMITTER: Latge G 

PROVIDER: S-EPMC5796072 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature