Mapping the Schizophrenia Genes by Neuroimaging: The Opportunities and the Challenges.

ABSTRACT: Schizophrenia (SZ) is a heritable brain disease originating from a complex interaction of genetic and environmental factors. The genes underpinning the neurobiology of SZ are largely unknown but recent data suggest strong evidence for genetic variations, such as single nucleotide polymorphisms, making the brain vulnerable to the risk of SZ. Structural and functional brain mapping of these genetic variations are essential for the development of agents and tools for better diagnosis, treatment and prevention of SZ. Addressing this, neuroimaging methods in combination with genetic analysis have been increasingly used for almost 20 years. So-called imaging genetics, the opportunities of this approach along with its limitations for SZ research will be outlined in this invited paper. While the p

SUBMITTER: Arslan A 

PROVIDER: S-EPMC5796168 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature