Association between receptor interacting serine/threonine kinase 2 polymorphisms and gastric cancer susceptibility.

ABSTRACT: The present study aimed to investigate whether single nucleotide polymorphisms in receptor interacting serine/threonine kinase 2 (RIPK2), which encodes a component of the nucleotide binding oligomerization domain containing 2-RIP2 pathway, may compromise the innate immune response to Helicobacter pylori infection, leading to increased susceptibility to gastric cancer in the Japanese population. The present case control study investigated the associations between RIPK2 single nucleotide polymorphisms and gastric mucosal inflammation, atrophy and cancer susceptibility in 528 patients with gastric cancer and 697 patients without gastric malignancies on upper gastro-duodenal endoscopy. Overall, the RIPK2 rs16900627 minor allele was significantly associated with the susceptibility to gastric ca

SUBMITTER: Ota M 

PROVIDER: S-EPMC5796317 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature