Existing creatinine-based equations overestimate glomerular filtration rate in Indians.

ABSTRACT:

Background

Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correction factors in the originally developed creatinine-based GFR estimation equations for populations around the world. Existing equations have not been validated in the vegetarian Indian population. We examined the performance of creatinine and cystatin-based GFR estimating equations in Indians.

Methods

GFR was measured by urinary clearance of inulin. Serum creatinine was measured using IDMS-traceable Jaffe's and enzymatic assays, and cystatin C by colloidal gold immunoassay. Dietary protein intake was calculated by measuring urinary nitrogen appearance. Bias, p

SUBMITTER: Kumar V 

PROVIDER: S-EPMC5796440 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature