Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system.

ABSTRACT:

Background

The use of biopolymers is increasing in drug delivery, thanks to the peculiar properties of these compounds such as their biodegradability, availability, and the possibility of modulating their physico-chemical characteristics. In particular, protein-based systems such as albumin are able to interact with many active compounds, modulating their biopharmaceutical properties. Zein is a protein of 20-40 kDa made up of many hydrophobic amino acids, generally regarded as safe (GRAS) and used as a coating material.

Methods

In this investigation, zein was combined with various surfactants in order to obtain stable nanosystems by means of the nanoprecipitation technique. Specific parameters, eg, temperature, pH value, Turbiscan Stability Index, serum stability, in vitro c

SUBMITTER: Gagliardi A 

PROVIDER: S-EPMC5796468 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature