Mechanical induction of dentin-like differentiation by adult mouse bone marrow stromal cells using compressive scaffolds.

ABSTRACT: Tooth formation during embryogenesis is controlled through a complex interplay between mechanical and chemical cues. We have previously shown that physical cell compaction of dental mesenchyme cells during mesenchymal condensation is responsible for triggering odontogenic differentiation during embryogenesis, and that expression of Collagen VI stabilizes this induction. In addition, we have shown that synthetic polymer scaffolds that artificially induce cell compaction can induce embryonic mandible mesenchymal cells to initiate tooth differentiation both in vitro and in vivo. As embryonic cells would be difficult to use for regenerative medicine applications, here we explored whether compressive scaffolds coated with Collagen VI can be used to induce adult bone marrow stromal cells (BMSCs)

SUBMITTER: Hashmi B 

PROVIDER: S-EPMC5796538 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature