Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset design.

ABSTRACT:

Background

Prior promising results have been reported with deep brain stimulation (DBS) of the anterior limb of the internal capsule in cases with severe obsessive compulsive disorder (OCD) who had exhausted conventional therapies.

Methods

In this pilot study, six adult patients (2 male; 4 female) meeting stringent criteria for severe (minimum Yale-Brown Obsessive Compulsive Scale [Y-BOCS] of 28) and treatment-refractory OCD had DBS electrode arrays placed bilaterally in an area spanning the ventral anterior limb of the internal capsule and adjacent ventral striatum referred to as the ventral capsule/ventral striatum. Using a randomized, staggered-onset design, patients were stimulated at either 30 or 60 days following surgery under blinded conditions.

Results

After 1

SUBMITTER: Goodman WK 

PROVIDER: S-EPMC5796545 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature