Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy.

ABSTRACT: Psychopathy is a personality disorder with strong links to criminal behavior. While research on psychopathy has focused largely on socio-affective dysfunction, recent data suggest that aberrant decision making may also play an important role. Yet, the circuit-level mechanisms underlying maladaptive decision making in psychopathy remain unclear. Here, we used a multi-modality functional imaging approach to identify these mechanisms in a population of adult male incarcerated offenders. Psychopathy was associated with stronger subjective value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice and with weaker intrinsic functional connectivity between NAcc and ventromedial prefrontal cortex (vmPFC). NAcc-vmPFC connectivity strength was negatively correlated with

SUBMITTER: Hosking JG 

PROVIDER: S-EPMC5796650 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature