Chronic early childhood exposure to arsenic is associated with a TNF-mediated proteomic signaling response.

ABSTRACT: Exposure to inorganic arsenic (iAs) in drinking water is a global public health concern and is associated with a range of health outcomes, including immune dysfunction. Children are a particularly sensitive population to the effects of inorganic arsenic, yet the biological mechanisms underlying adverse health outcomes are understudied. Here we used a proteomic approach to examine the effects of iAs exposure on circulating serum protein levels in a cross-sectional children's cohort in Mexico. To identify iAs-associated proteins, levels of total urinary arsenic (U-tAs) and its metabolites were determined and serum proteins assessed for differences in expression. The results indicate an enrichment of Tumor Necrosis Factor-(TNF)-regulated immune and inflammatory response proteins that displaye

SUBMITTER: Smeester L 

PROVIDER: S-EPMC5796657 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature