Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection.

ABSTRACT: Acute respiratory tract viral infections (ARTIs) cause significant morbidity and mortality. CD8 T cells are fundamental to host responses, but transcriptional alterations underlying anti-viral mechanisms and links to clinical characteristics remain unclear. CD8 T cell transcriptional circuitry in acutely ill pediatric patients with influenza-like illness was distinct for different viral pathogens. Although changes included expected upregulation of interferon-stimulated genes (ISGs), transcriptional downregulation was prominent upon exposure to innate immune signals in early IFV infection. Network analysis linked changes to severity of infection, asthma, sex, and age. An influenza pediatric signature (IPS) distinguished acute influenza from other ARTIs and outperformed other influenza predi

SUBMITTER: Henrickson SE 

PROVIDER: S-EPMC5796675 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature