Simulation and Experimental Assembly of DNA-Graft Copolymer Micelles with Controlled Morphology.

ABSTRACT: Nanoparticles formed through complexation of plasmid DNA and copolymers are promising gene-delivery vectors, offering a wide range of advantages over alternative delivery strategies. Notably, recent research has shown that the shape of these particles can be tuned, which makes it possible to gain understanding of their shape-dependent transfection properties. Whereas earlier methods achieved shape tuning through the use of block copolymers and variation of solvent polarity, here we demonstrate through a combined experimental and computational approach that the same degree of shape control can be achieved through the use of graft copolymers that are easier to synthesize and provide a wider range of parameters for shape control. Moreover, the approach presented here does not require the use

SUBMITTER: We Z 

PROVIDER: S-EPMC5796780 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature