Ontology highlight
ABSTRACT:
SUBMITTER: Cao K
PROVIDER: S-EPMC5796793 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cao Kaixiang K Collings Clayton K CK Morgan Marc A MA Marshall Stacy A SA Rendleman Emily J EJ Ozark Patrick A PA Smith Edwin R ER Shilatifard Ali A
Science advances 20180131 1
Chromatin regulators control cellular differentiation by orchestrating dynamic developmental gene expression programs, and hence, malfunctions in the regulation of chromatin state contribute to both developmental disorders and disease state. Mll4 (Kmt2d), a member of the COMPASS (COMplex of Proteins ASsociated with Set1) protein family that implements histone H3 lysine 4 monomethylation (H3K4me1) at enhancers, is essential for embryonic development and functions as a pancancer tumor suppressor. ...[more]