Acute kidney injury and infections in patients taking antihypertensive drugs: a self-controlled case series analysis.

ABSTRACT:

Background

The relative risk of acute kidney injury (AKI) following different infections, and whether angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) modify the risk, is unclear. We aimed to determine the risks of hospital admission with AKI following infections (urinary tract infection [UTI], lower respiratory tract infection [LRTI], and gastroenteritis) among users of antihypertensive drugs.

Methods

We used UK electronic health records from practices contributing to the Clinical Practice Research Datalink linked to the Hospital Episode Statistics database. We identified adults initiating ACEIs/ARBs or alternative antihypertensive therapy (β-blockers, calcium channel blockers, or thiazide diuretics) between April 1997 and March 2014 wit

SUBMITTER: Mansfield KE 

PROVIDER: S-EPMC5796801 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature