Maternal Multivitamin Intake, Plasma Folate and Vitamin B₁₂ Levels and Autism Spectrum Disorder Risk in Offspring.

ABSTRACT:

Background

To examine the prospective association between multivitamin supplementation during pregnancy and biomarker measures of maternal plasma folate and vitamin B₁₂ levels at birth and child's Autism Spectrum Disorder (ASD) risk.

Methods

This report included 1257 mother-child pairs, who were recruited at birth and prospectively followed through childhood at the Boston Medical Center. ASD was defined from diagnostic codes in electronic medical records. Maternal multivitamin supplementation was assessed via questionnaire interview; maternal plasma folate and B₁₂ were measured from samples taken 2-3 days after birth.

Results

Moderate (3-5 times/week) self-reported supplementation during pregnancy was associated with decreased risk of ASD, consis

SUBMITTER: Raghavan R 

PROVIDER: S-EPMC5796848 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature