Co-administration of iRGD with peptide HPRP-A1 to improve anticancer activity and membrane penetrability.

ABSTRACT: To improve the specificity and penetration of anticancer peptides against tumors, in this study, we examined the effects of co-administration of the membrane-active peptide HPRP-A1 and the tumor homing/penetrating peptide iRGD. iRGD peptide is widely recognized as an efficient cell membrane penetration peptide targeting to α_vβ₃ integrins and neuropilin-1 (NRP-1) receptors, which show high expression in many tumor cells. The anticancer activity, cancer specificity and penetration activity in vitro and in vivo of the co-administered peptides were examined on 2D monolayer cells, 3D multi-cellular spheroids (MCS) and xenograft nude mice. Co-administration of iRGD and HPRP-A1 exhibited stronger anticancer activity and tumor specificity against A549 non-small cell lung canc

SUBMITTER: Hu C 

PROVIDER: S-EPMC5797073 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature