Targeted plasma proteomics identifies a novel, robust association between cornulin and Swedish moist snuff.

ABSTRACT: Lifestyle behaviors are believed to influence the body's inflammatory state. Chronic low-grade inflammation contributes to the development of major non-communicable diseases such as diabetes, cardiovascular disease and cancer. Inflammation may thus be an important link between lifestyle and disease. We evaluated self-reported physical activity, tobacco use and alcohol consumption in relation to plasma levels of 160 validated inflammatory and cancer biomarkers. The study included 138 participants from a population-based cohort, all with repeated sampling of plasma and data ten years apart, allowing consideration of both intra- and inter-individual variation. Of 17 relationships identified, the strongest was an independent, positive association between cornulin (CRNN) and Swedish moist snuff

SUBMITTER: Sundkvist A 

PROVIDER: S-EPMC5797131 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature