An Accord of Nuclear Receptor Expression in M. tuberculosis Infected Macrophages and Dendritic Cells.

ABSTRACT: Mycobacterium tuberculosis instigates interactions with host factors to promote its survival within the host inimical conditions. Among such factors, nuclear receptors (NRs) seem to be promising candidates owing to their role in bacterial pathogenesis. However, only few members of NR superfamily have been implicated in M. tuberculosis infection and there is a dearth of comprehensive knowledge about expression or function of the entire superfamily. In this study, we performed detailed expression analysis and identified key NRs getting differentially regulated in murine macrophages and dendritic cells (DC) upon infection with H37Rv. The murine macrophages and DCs infected with H37Rv entailed overlapping changes in the expression of certain NRs which reflect upon the possibility that both cel

SUBMITTER: Saini A 

PROVIDER: S-EPMC5797181 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature