In vivo microbiome and associated immune markers: New insights into the pathogenesis of vaginal dysbiosis.

ABSTRACT: The microbiota fulfils a key role in the training and function of the immune system, which contributes to the symbiosis between the host and complex microbial communities. In this study, we characterized the interplay between vaginal bacteria and local immune mediators during dysbiosis in selected women of reproductive age who were grouped according to Nugent's criteria. The abundance of Gardnerella vaginalis and Bifidobacterium breve was increased in the intermediate dysbiotic status, while the presence of a plethora of non-resident bacteria characterized the group with overt vaginosis. In response to these increases, the anti-inflammatory IL1ra and pro-inflammatory IL2 increased, while the embryo trophic factors FGFβ and GMCSF decreased compared to the healthy milieu. A specific pattern,

SUBMITTER: Campisciano G 

PROVIDER: S-EPMC5797242 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature