Long-term preservation of planar cell polarity in reversed tracheal epithelium.

ABSTRACT:

Background

Planar cell polarity (PCP) coordinates the patterning and orientation of cells and their structures along tissue planes, and although its acquisition during the formation of airway epithelium has been described, the mechanisms for its maintenance and reconstruction are poorly understood. We aimed to clarify whether ambient environment change by orthotropic autologous transplantation affected PCP at the cellular level.

Methods

We performed orthotropic autologous transplantation by inverting tracheal segments in rats, and then performed morphological evaluation by microscopy. The PCP of the tracheal epithelium was assessed over time by analyzing the directions of mucociliary transport and ciliary beat, the positional relationship between the basal body and basal foo

SUBMITTER: Tsuji T 

PROVIDER: S-EPMC5797350 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature