Feasibility of a brief, intensive weight loss intervention to improve reproductive outcomes in obese, subfertile women: a pilot study.

ABSTRACT:

Objective

To evaluate the feasibility of a brief, intensive weight loss intervention (IWL) to improve reproductive outcomes in obese subfertile women.

Design

Pilot study of IWL versus standard-of-care nutrition counseling (SCN).

Setting

Single-site, academic institution.

Patient(s)

Obese women (body mass index, 35-45 kg/m²) with anovulatory subfertility.

Intervention(s)

Women were rigorously prescreened to rule out secondary causes of subfertility. Eligible women were randomized to IWL or SCN. IWL consisted of 12 weeks of very-low-energy diet (800 kcal/day) + 4 weeks of a low-calorie conventional food-based diet (CFD) to promote 15% weight loss. SCN consisted of 16 weeks of CFD to promote ≥5% weight loss. Women were transitioned to weight main

SUBMITTER: Rothberg A 

PROVIDER: S-EPMC5797426 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature