Identification of genomic expression differences between right-sided and left-sided colon cancer based on bioinformatics analysis.

ABSTRACT:

Introduction

More and more findings have demonstrated that right-sided colon cancers (RCC) and left-sided colon cancers (LCC) are distinct clinical and biological entities and suggest that they should be treated as different diseases. However, the reasons why RCC and LCC harbor different clinical and biological features remain unclear.

Materials and methods

To identify the genomic expression differences between RCC and LCC and uncover the mechanisms underlying these differences, we chose the gene expression profiles of GSE14333 from the Gene Expression Omnibus (GEO) database as an object of study. Then, a systematic and integrative bioinformatics analysis was performed to research the possible mechanism of the differentially expressed (DE) genes from the Gene Expression Omni

SUBMITTER: Peng Q 

PROVIDER: S-EPMC5797455 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature