TGF-β-Induced CD8⁺CD103⁺ Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells.

ABSTRACT: Lupus nephritis is one of most severe complications of systemic erythematosus lupus and current approaches are not curative for lupus nephritis. Although CD4⁺Foxp3⁺ regulatory T cells (Treg) are crucial for prevention of autoimmunity, the therapeutic effect of these cells on lupus nephritis is not satisfactory. We previously reported that CD8⁺CD103⁺ Treg induced ex vivo with TGF-β1 and IL-2 (CD8⁺CD103⁺ iTreg), regardless of Foxp3 expression, displayed potent immunosuppressive effect on Th cell response and had therapeutic effect on Th cell-mediated colitis. Here, we tested whether CD8⁺CD103⁺ iTreg can ameliorate lupus nephritis and determined potential molecular mechanisms. Adoptive transfer of C

SUBMITTER: Zhong H 

PROVIDER: S-EPMC5797539 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature