Cardiovascular magnetic resonance imaging to assess myocardial fibrosis in valvular heart disease.

ABSTRACT: The left ventricular (LV) remodeling process associated with significant valvular heart disease (VHD) is characterized by an increase of myocardial interstitial space with deposition of collagen and loss of myofibers. These changes occur before LV systolic function deteriorates or the patient develops symptoms. Cardiovascular magnetic resonance (CMR) permits assessment of reactive fibrosis, with the use of T1 mapping techniques, and replacement fibrosis, with the use of late gadolinium contrast enhancement. In addition, functional consequences of these structural changes can be evaluated with myocardial tagging and feature tracking CMR, which assess the active deformation (strain) of the LV myocardium. Several studies have demonstrated that CMR techniques may be more sensitive than the con

SUBMITTER: Podlesnikar T 

PROVIDER: S-EPMC5797565 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature