Altered Brain Functional Connectome in Migraine with and without Restless Legs Syndrome: A Resting-State Functional MRI Study.

ABSTRACT:

Background

Migraine is frequently comorbid with restless legs syndrome (RLS), both displaying functional connectivity (FC) alterations in multiple brain networks, although the neurological basis of this association is unknown.

Methods

We performed resting-state functional magnetic resonance imaging and network-wise analysis of FC in migraine patients with and without RLS and healthy controls (CRL). Network-based statistics (NBS) and composite FC matrix analyses were performed to identify the patterns of FC changes. Correlation analyses were performed to identify associations between alterations in FC and clinical profiles.

Results

NBS results revealed that both migraine patients with and without RLS exhibited lower FC than CRL in the dorsal attention, salience, defaul

SUBMITTER: Yang FC 

PROVIDER: S-EPMC5797592 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature