Inverse Modulation of Neuronal K_v12.1 and K_v11.1 Channels by 4-Aminopyridine and NS1643.

ABSTRACT: The three members of the ether-à-go-go-gene-like (Elk; K_v12.1-K_v12.3) family of voltage-gated K⁺ channels are predominantly expressed in neurons, but only little information is available on their physiological relevance. It was shown that K_v12.2 channels modulate excitability of hippocampal neurons, but no native current could be attributed to K_v12.1 and K_v12.3 subunits yet. This may appear somewhat surprising, given high expression of their mRNA transcripts in several brain areas. Native K_v12 currents may have been overlooked so far due to limited knowledge on their biophysical properties and lack of specific pharmacology. Except for K_v12.2, appropriate genetically modified mouse models have not

SUBMITTER: Dierich M 

PROVIDER: S-EPMC5797642 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature