Epithelial-derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection.

ABSTRACT: Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate immune activation and consequent pathology. Epithelial cells have a vital role orchestrating pulmonary homeostasis and defense against pathogens. TGF-β regulates an array of immune responses-both inflammatory and regulatory-however, its function is highly location- and context-dependent. We demonstrate that epithelial-derived TGF-β acts as a pro-viral factor suppressing early immune responses during influenza A infection. Mice specifically lacking bronchial epithelial TGF-β1 (epTGFβKO) displayed marked protection from influenza-induced weight loss, airway inflammation, and pathology. However, protection from influenza-induced pathology wa

SUBMITTER: Denney L 

PROVIDER: S-EPMC5797694 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature