Proliferation genes in lung development associated with the prognosis of lung adenocarcinoma but not squamous cell carcinoma.

ABSTRACT: There are many similarities between embryonic development and tumorigenesis, and gene expression profiles show that certain correlations exist between the gene signature during development and the clinical phenotypes of different cancers. Our group previously reported the gene expression profiles of human lung development, and the expression of one group of proliferation-related genes (PTN1 genes) steadily decreased during lung development. Here, we examined the prognostic value of PTN1 genes in 5 independent lung adenocarcinoma (ADC) and 5 lung independent squamous cell carcinoma (SCC) microarray datasets and found that the expression levels of PTN1 genes were associated with survival in lung ADC but not lung SCC. All of the lung ADC datasets contained a set of highly correlated genes fro

SUBMITTER: Li P 

PROVIDER: S-EPMC5797819 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature