Mouse Models of Influenza Infection with Circulating Strains to Test Seasonal Vaccine Efficacy.

ABSTRACT: Influenza virus infection is a significant cause of morbidity and mortality worldwide. The surface antigens of influenza virus change over time blunting both naturally acquired and vaccine induced adaptive immune protection. Viral antigenic drift is a major contributing factor to both the spread and disease burden of influenza. The aim of this study was to develop better infection models using clinically relevant, influenza strains to test vaccine induced protection. CB6F1 mice were infected with a range of influenza viruses and disease, inflammation, cell influx, and viral load were characterized after infection. Infection with circulating H1N1 and representative influenza B viruses induced a dose-dependent disease response; however, a recent seasonal H3N2 virus did not cause any disease

SUBMITTER: Groves HT 

PROVIDER: S-EPMC5797846 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature