Proton Pump Inhibitors and Risk of Mild Cognitive Impairment and Dementia.

ABSTRACT:

Objectives

To examine the risk associated with the use of proton pump inhibitors (PPIs) of conversion to mild cognitive impairment (MCI), dementia, and specifically Alzheimer's disease (AD).

Design

Observational, longitudinal study.

Setting

Tertiary academic Alzheimer's Disease Centers funded by the National Institute on Aging.

Participants

Research volunteers aged 50 and older with two to six annual visits; 884 were taking PPIs at every visit, 1,925 took PPIs intermittently, and 7,677 never reported taking PPIs. All had baseline normal cognition or MCI.

Measurements

Multivariable Cox regression analyses evaluated the association between PPI use and annual conversion of baseline normal cognition to MCI or dementia or annual conversion of baseline MCI to

SUBMITTER: Goldstein FC 

PROVIDER: S-EPMC5797939 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature