The bright and the dark side of human antibody responses to flaviviruses: lessons for vaccine design.

ABSTRACT: Zika and dengue viruses belong to the Flavivirus genus, a close group of antigenically related viruses that cause significant arthropod-transmitted diseases throughout the globe. Although infection by a given flavivirus is thought to confer lifelong protection, some of the patient's antibodies cross-react with other flaviviruses without cross-neutralizing. The original antigenic sin phenomenon may amplify such antibodies upon subsequent heterologous flavivirus infection, potentially aggravating disease by antibody-dependent enhancement (ADE). The most striking example is provided by the four different dengue viruses, where infection by one serotype appears to predispose to more severe disease upon infection by a second one. A similar effect was postulated for sequential infections with Zik

SUBMITTER: Rey FA 

PROVIDER: S-EPMC5797954 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature