E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.
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ABSTRACT:
SUBMITTER: Vuillier C
PROVIDER: S-EPMC5797968 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
E2F1 interacts with BCL-xL and regulates its subcellular localization dynamics to trigger cell death.
Vuillier Céline C Lohard Steven S Fétiveau Aurélie A Allègre Jennifer J Kayaci Cémile C King Louise E LE Braun Frédérique F Barillé-Nion Sophie S Gautier Fabien F Dubrez Laurence L Gilmore Andrew P AP Juin Philippe P PP Maillet Laurent L
EMBO reports 20171212 2
E2F1 is the main pro-apoptotic effector of the pRB-regulated tumor suppressor pathway by promoting the transcription of various pro-apoptotic proteins. We report here that E2F1 partly localizes to mitochondria, where it favors mitochondrial outer membrane permeabilization. E2F1 interacts with BCL-xL independently from its BH3 binding interface and induces a stabilization of BCL-xL at mitochondrial membranes. This prevents efficient control of BCL-xL over its binding partners, in particular over ...[more]
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