Effects of varenicline on cognitive performance in heavy drinkers: Dose-response effects and associations with drinking outcomes.

ABSTRACT: Varenicline reduces drinking in people with alcohol use disorder, but little is known about the mechanisms underlying this effect. Varenicline targets α4β2 and α7 nicotinic acetylcholine receptors, which are associated with several cognitive functions such as working memory. Varenicline may improve drinking outcomes by enhancing cognitive functioning. The current manuscript reports on cognitive outcomes from a placebo-controlled, double-blind human laboratory experiment examining the effects of varenicline on drinking behavior (Verplaetse et al., 2016a). Participants were 55 adult heavy drinkers who met criteria for an alcohol use disorder. They were randomized to receive varenicline (1 mg/day, 2 mg/day) or placebo. They completed a baseline assessment of cognitive functioning (i.e., digit

SUBMITTER: Roberts W 

PROVIDER: S-EPMC5797996 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature