Tumor-associated macrophages remodeling EMT and predicting survival in colorectal carcinoma.

ABSTRACT: The immune contexture, a composition of the tumor microenvironment, plays multiple important roles in cancer stem cell (CSC) and epithelial-mesenchymal transition (EMT), and hence critically influences tumor initiation, progression and patient outcome. Tumor-associated macrophages (TAMs) are abundant in immune contexture, however their roles in CSC, EMT and prognosis of colorectal cancer (CRC) have not been elucidated. In 419 colorectal carcinomas, immune cell types (CD68⁺ macrophages, CD3⁺, CD4⁺ or CD8⁺ T lymphocytes, CD20⁺ B lymphocytes), EMT markers (E-cadherin and Snail) as well as the stem cell marker (CD44v6) were detected in tumor center (TC) and tumor invasive front (TF) respectively by immunohistochemistry. Tumor buds, that re

SUBMITTER: Li S 

PROVIDER: S-EPMC5798198 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature