Metformin prevents ischaemic ventricular fibrillation in metabolically normal pigs.

ABSTRACT:

Aims/hypothesis

Metformin is the drug most often used to treat type 2 diabetes. Evidence suggests that metformin may reduce mortality of individuals with type 2 diabetes, but the mechanism of such an effect is unknown and outcomes of metformin treatment in people without diabetes have not been determined. If metformin favourably affected mortality of non-diabetic individuals, it might have even broader therapeutic utility. We evaluated the effect of metformin on myocardial energetics and ischaemic ventricular fibrillation (VF) in metabolically normal pigs.

Methods

Domestic farm pigs were treated with metformin (30 mg kg^-1 day^-1 orally for 2-3 weeks; n = 36) or received no treatment (n = 37). Under anaesthesia, pigs underwent up to 90 min low-flow region

SUBMITTER: Lu L 

PROVIDER: S-EPMC5798228 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature