Complement pathway gene activation and rising circulating immune complexes characterize early disease in HIV-associated tuberculosis.

ABSTRACT: The transition between latent and active tuberculosis (TB) occurs before symptom onset. Better understanding of the early events in subclinical disease will facilitate the development of diagnostics and interventions that improve TB control. This is particularly relevant in the context of HIV-1 coinfection where progression of TB is more likely. In a recent study using [¹⁸F]-fluoro-2-deoxy-d-glucose positron emission/computed tomography (FDG-PET/CT) on 35 asymptomatic, HIV-1-infected adults, we identified 10 participants with radiographic evidence of subclinical disease, significantly more likely to progress than the 25 participants without. To gain insight into the biological events in early disease, we performed blood-based whole genome transcriptomic analysis on these partici

SUBMITTER: Esmail H 

PROVIDER: S-EPMC5798330 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature