Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement.

ABSTRACT: Coordinated changes in gene expression underlie the early patterning and cell-type specification of the central nervous system. However, much less is known about how such changes contribute to later stages of circuit assembly and refinement. In this study, we employ single-cell RNA sequencing to develop a detailed, whole-transcriptome resource of gene expression across four time points in the developing dorsal lateral geniculate nucleus (LGN), a visual structure in the brain that undergoes a well-characterized program of postnatal circuit development. This approach identifies markers defining the major LGN cell types, including excitatory relay neurons, oligodendrocytes, astrocytes, microglia, and endothelial cells. Most cell types exhibit significant transcriptional changes across develop

SUBMITTER: Kalish BT 

PROVIDER: S-EPMC5798372 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature