Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study.

ABSTRACT:

Objective

To examine whether genetically predicted variation in circulating insulin-like growth factor 1 (IGF1) or its binding protein, IGFBP3, are associated with risk of Alzheimer disease (AD), using a mendelian randomization study design.

Methods

We first examined disease risk by genotypes of 9 insulin-like growth factor (IGF)-related single nucleotide polymorphisms (SNPs) using published summary genome-wide association statistics from the International Genomics of Alzheimer's Project (IGAP; n = 17,008 cases; 37,154 controls). We then assessed whether any SNP-disease results replicated in an independent sample derived from the Swedish Twin Registry (n = 984 cases; 10,304 controls).

Results

Meta-analyses of SNP-AD results did not suggest that variation in IGF1, IGFB

SUBMITTER: Williams DM 

PROVIDER: S-EPMC5798653 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature